New Oral Formulation and in Vitro Evaluation of Docetaxel-Loaded Nanomicelles
نویسندگان
چکیده
منابع مشابه
New Oral Formulation and in Vitro Evaluation of Docetaxel-Loaded Nanomicelles.
Intravenous administration of Taxotere® (a commercial form of docetaxel, DTX) leads to many problems such as hypersensitivity, hemolysis, cutaneous allergy, and patient refusal due to its prolonged injection. The oral absorption of DTX is very low due to its hydrophobic nature. The purpose of this study was to prepare and carry out an in vitro evaluation of DTX-loaded nanomicelles for oral admi...
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A mixed micelle that comprised of monomethylol poly(ethylene glycol)-poly(D,L-lactic acid) (MPP), D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) and stearic acid grafted chitosan oligosaccharide(CSO-SA) copolymers was developed to enhance the oral absorption of docetaxel (DTX). DTX-loaded MPP/TPGS/CSO-SA mixed polymeric micelles (MPMs) were prepared with thin film hydration method and...
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ژورنال
عنوان ژورنال: Molecules
سال: 2016
ISSN: 1420-3049
DOI: 10.3390/molecules21091265